|
Symbol Name ID |
Vcp
valosin containing protein MGI:99919 |
| Darker colors indicate more annotations |
| Human Phenotypes | Facial palsy |
Ankle clonus |
Absent Achilles reflex |
Dysphagia |
Spasticity |
Lower limb spasticity |
Difficulty walking |
Frequent falls |
Abnormal lower motor neuron morphology |
Amyotrophic lateral sclerosis |
Peripheral axonal neuropathy |
Frontal cortical atrophy |
Temporal cortical atrophy |
Brain atrophy |
Poor fine motor coordination |
Fasciculations |
Babinski sign |
Tetraparesis |
Decreased motor nerve conduction velocity |
Decreased nerve conduction velocity |
Aphasia |
Dysarthria |
Depression |
Emotional lability |
Atypical behavior |
Personality changes |
Memory impairment |
Dementia |
Frontotemporal dementia |
Brisk reflexes |
Reduced tendon reflexes |
Hyporeflexia |
Dystonia |
Gait disturbance |
Broad-based gait |
Gait imbalance |
Loss of ambulation |
Steppage gait |
Tip-toe gait |
Sensorimotor neuropathy |
Impaired pain sensation |
Impaired tactile sensation |
Impaired distal tactile sensation |
Paresthesia |
Distal sensory impairment |
Abolished vibration sense |
Impaired distal vibration sensation |
Impaired vibration sensation in the lower limbs |
| Disease(s) Associated with VCP | ||||||||||||||||||||||||||||||||||||||||||||||||
| Charcot-Marie-Tooth disease type 2Y | ||||||||||||||||||||||||||||||||||||||||||||||||
| frontotemporal dementia and/or amyotrophic lateral sclerosis 6 | ||||||||||||||||||||||||||||||||||||||||||||||||
| inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1 | ||||||||||||||||||||||||||||||||||||||||||||||||
| inclusion body myositis |
| Mouse Phenotypes | seizures |
tonic-clonic seizures |
abnormal brain morphology |
decreased brain weight |
abnormal cerebral cortex morphology |
abnormal cerebral cortex pyramidal cell morphology |
abnormal primary motor cortex morphology |
abnormal stratification in cerebral cortex |
thin cerebral cortex |
abnormal frontal lobe morphology |
gliosis |
abnormal neuron morphology |
motor neuron degeneration |
decreased dendritic spine number |
decreased neuronal stem cell self-renewal |
|
| Availability | Mouse Genotype | |||||||||||||||
| Vcptm1Itl/Vcptm1Itl | ||||||||||||||||
| Vcptm1.1Hiok/Vcp+ | ||||||||||||||||
| Vcptm1Itl/Vcp+ | ||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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